Presentation of IgAN

Recognizing the heterogeneous presentation of IgAN is key to evaluating your patient's disease¹

FACTORS TO CONSIDER WHEN EVALUATING PATIENTS WITH IgAN¹

Click on image to enlarge.

In patients with IgAN, persistent proteinuria despite RASi ± SGLT2i can signify the need for a different approach^1-3

Initially, Fiona presented to her PCP with proteinuria, hematuria, edema, and hypertension. She was referred to her nephrologist, who found:

• Proteinuria (g/g): 1.8

• eGFR (mL/min/1.73 m²): 75

• Persistent microscopic hematuria

• BP (mm Hg): 140/90

Her nephrologist prescribed an ACEi and lifestyle changes (low-sodium diet and exercise).

Fiona's kidney biopsy at diagnosis:

• The biopsy revealed complement activation

• MEST-C score: M1, E1, S1, T0, C0

3-month follow-up after IgAN diagnosis:

• Proteinuria (g/g): 1.7

• Fiona was prescribed a course of steroids

After completion of a 6-month course on steroids:

• Proteinuria (g/g): 1.5

3 months after steroid completion:

• Proteinuria (g/g): 1.5

• Fiona and her nephrologist were not satisfied after completion of her course on steroids